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KMID : 0382420020280010067
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Korean Journal of Environmental Health Society
2002 Volume.28 No. 1 p.67 ~ p.78
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Determination of urinary metabolite of IBP afterl administration and dermal application to rats
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Min Kyung-Jin
Cho Young-Joo
Cha Chun-Geun
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Abstract
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This study was aimed to determine the urinary metabolite of lBP, one of the organophosphorus pesticides, as the biomarkers of exposure-Urine samples were collected for 24 hours in metabolic cages after oral administration and dermal application of IBP to rats ldentification of the derivatized urinary metabolite was determined by GC/MS and excretion time courses of the urinary metabolite was analyzed by GC/FPD. Urinary metabolite o IBP, diisopropyl phosphorothioate, was detected in rats urine both after oral administration and dermal application of IBP. Parent compound was no! detected in the experiment.
In GC/MS, the mass spectral confirmation for diisopropyl phosphorothioate ion was identified at m/z 254. Diisopropyl phosphorothioate was excreted within 48 hours and 72 hours after oral administration and dermal application of IBP, respectively.
In this study, the same urinary metabolite of lBP was detected both in oral and dermal exposure. Generally, excretion of the urinary metaboule afler oral admin!stratlon was faster than after dermal appllcalmn. It is sugEested that urinary diisopropyl phosphorothioate could be used as the biomarkers of exposure to IBP.
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